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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RRLSYSRRRF | succinic acid | 2-pyrrolinodoxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01389 |
| Smiles | |
| Molecular weight | 2242.06 |
| Molecular formula | C106H143N27O28 |
| Chemical name | Peptide information |
| Sequence (one letter) | RRLSYSRRRF |
| Length | 10 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 757967-31-0 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | enhance cellular uptake and overcome multidrug resistance |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | succinic acid |
| Small molecule | 2-pyrrolinodoxorubicin |
| Small molecule CAS | 175795-76-3 |
| Structure method | HPLC, LC/MS/MS |
| Calculated properties | |
|---|---|
| LogP | -4.51950 |
| Rotatable bonds | 62 |
| H bond donor | 34 |
| H bond acceptor | 41 |
| Polar surface area (PSA) | 928.73000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
2-Pyrrolinodoxorubicin and its peptide-vectorized form bypass multidrug resistance | 2004 | Castex, Cedric; Merida, Peggy; Blanc, Emmanuelle; Clair, Philippe; Rees, Anthony R.; Temsamani, Jamal | Anti-Cancer Drugs | ||
