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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| EEE | Naproxen |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00985 |
| Smiles | |
| Molecular weight | 1133.39 |
| Molecular formula | C49H63N7O24 |
| Chemical name | Peptide information |
| Sequence (one letter) | EEE |
| Length | 3 |
| Peptide name | tripeptide |
| External ID | |
|---|---|
| CAS number | 1186099-39-7 |
| Other information | |
|---|---|
| Application | bone-targeting (prodrug) |
| Additional function | Inreased water solubility |
| Pharmacological class | Anti-inflammatory |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Naproxen |
| Small molecule CAS | 22204-53-1 |
| Small molecule structure | |
| Structure method | 1H NMR, MS |
| NMR solvent | CDCl3 or D2O |
| Calculated properties | |
|---|---|
| LogP | -3.24190 |
| Rotatable bonds | 38 |
| H bond donor | 15 |
| H bond acceptor | 24 |
| Polar surface area (PSA) | 511.33000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and preliminary evaluation in vitro of novel naproxen-dendritic peptide conjugates | 2009 | Ouyang, Liang; Zhang, Jing; Pan, Junzhu; Yan, Linna; Guo, Li | Drug Delivery | ||
