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View Conjugates details

ConjuPepDB ID: cpd00923

Chemical structure


molecule
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cpd00923


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
GPLGIAGQ pacitaxel derivative
Identification
ConjuPepDB ID

cpd00923

Smiles
Inchi Key

InChIKey=JZQNLPLPCIHSBX-HYUBKVMMSA-N

Molecular weight

1588.72

Molecular formula

C80H104N10O24

Chemical name
Peptide information
Sequence (one letter)

GPLGIAGQ

Length

8

Peptide name

octapeptide recognized and cleaved by MMP3

External ID
CAS number

1293910-28-7

Other information
Application

Antitumor therapy

Additional function

Targeting overexpressing MMP2, enhance efficacy

Conjugate type

ester

Linker

no

Small molecule

pacitaxel derivative

Small molecule CAS

114655-02-6

Small molecule structure

Structure method

1H- and 13C-NMR

NMR solvent

CDCl3

Calculated properties
LogP

-0.31973

Rotatable bonds

38

H bond donor

11

H bond acceptor

19

Polar surface area (PSA)

494.46000

Citations
ID Title Year Authors Journal DOI

Cpdart0131

Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery

2010

Yamada, Roppei; Kostova, Maya B.; Anchoori, Ravi Kumar; Xu, Shili; Neamati, Nouri; Khan, Saeed R.

Cancer Biology & Therapy

..