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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GPLGIAGQ | pacitaxel derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00922 |
| Smiles | |
| Inchi Key | InChIKey=LDTRXOPGXBGOCU-OKNZPZJZSA-N |
| Molecular weight | 1702.81 |
| Molecular formula | C86H118N10O24Si |
| Chemical name | Peptide information |
| Sequence (one letter) | GPLGIAGQ |
| Length | 8 |
| Peptide name | octapeptide recognized and cleaved by MMP2 |
| External ID | |
|---|---|
| CAS number | 1293910-29-8 |
| Other information | |
|---|---|
| Application | Antitumor therapy, MDA-MB-435 and HT1080 cells |
| Additional function | Targeting overexpressing MMP2, enhance efficacy |
| Conjugate type | ester |
| Linker | no |
| Small molecule | pacitaxel derivative |
| Small molecule CAS | 114655-02-6 |
| Small molecule structure | |
| Structure method | 1H- and 13C-NMR |
| NMR solvent | CDCl3 |
| Calculated properties | |
|---|---|
| LogP | 2.12650 |
| Rotatable bonds | 41 |
| H bond donor | 10 |
| H bond acceptor | 19 |
| Polar surface area (PSA) | 483.46000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery | 2010 | Yamada, Roppei; Kostova, Maya B.; Anchoori, Ravi Kumar; Xu, Shili; Neamati, Nouri; Khan, Saeed R. | Cancer Biology & Therapy | ||
