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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| FCFWWKTFG | butyramide | 5-[[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]amino]-5-oxo-Pentanoic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00231 |
| Smiles | |
| Inchi Key | InChIKey=AIHJLSQGCCDTNH-SJTUSTMXSA-N |
| Molecular weight | 1741.76 |
| Molecular formula | C91H107N17O15S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | FCFWWKTFG |
| Length | 9 |
| Peptide name | somatostatin backbone cyclic analog |
| External ID | |
|---|---|
| CAS number | 1841405-74-0 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | Targeting somatostatin expressing cells |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | butyramide |
| Small molecule | 5-[[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]amino]-5-oxo-Pentanoic acid |
| Small molecule CAS | 1841405-77-3 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | 2.52995 |
| Rotatable bonds | 32 |
| H bond donor | 15 |
| H bond acceptor | 17 |
| Polar surface area (PSA) | 472.85000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis, drug release, and biological evaluation of new anticancer drug-bioconjugates containing somatostatin backbone cyclic analog as a targeting moiety | 2015 | Redko, Boris; Ragozin, Elena; Andreii, Bazylevich; Helena, Tuchinsky; Amnon, Albeck; Talia, Shekhter Zahavi; Mor, Oron-Herman; Genady, Kostenich; Gary, Gellerman | Biopolymers | ||
