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View Conjugates details

ConjuPepDB ID: cpd00146

Chemical structure


molecule
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cpd00146


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
NFGAILSS 4-(Chlorocarbonyl)-1,2-benzenedicarboxylic acid
Identification
ConjuPepDB ID

cpd00146

Smiles
Inchi Key

InChIKey=HHGLCMZRMLZOSC-CBTREZALSA-N

Molecular weight

999.419

Molecular formula

C45H61N9O17

Chemical name
Peptide information
Sequence (one letter)

NFGAILSS

Length

8

Peptide name

amyloid disrupting peptide

External ID
CAS number

2130904-39-9

Other information
Application

Type 2 diabetes therapy, amylin aggregation inhibition

Additional function

Self-assembly

Pharmacological class

neurological

Conjugate type

amide

Linker

no

Small molecule

4-(Chlorocarbonyl)-1,2-benzenedicarboxylic acid

Small molecule CAS

53659-79-3

Small molecule structure

Calculated properties
LogP

-3.21500

Rotatable bonds

29

H bond donor

14

H bond acceptor

17

Polar surface area (PSA)

428.25000

Citations
ID Title Year Authors Journal DOI

Cpdart0036

Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation

2017

Profit, Adam A.; Vedad, Jayson; Desamero, Ruel Z. B.

Bioconjugate Chemistry

..