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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| NFGAILSS | 4-(Chlorocarbonyl)-1,2-benzenedicarboxylic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00145 |
| Smiles | |
| Inchi Key | InChIKey=XWXXTBYZVFQVPV-CBTREZALSA-N |
| Molecular weight | 999.419 |
| Molecular formula | C45H61N9O17 |
| Chemical name | Peptide information |
| Sequence (one letter) | NFGAILSS |
| Length | 8 |
| Peptide name | amyloid disrupting peptide |
| External ID | |
|---|---|
| CAS number | 2130904-40-2 |
| Other information | |
|---|---|
| Application | Type 2 diabetes therapy, amylin aggregation inhibition |
| Additional function | Self-assembly |
| Pharmacological class | neurological |
| Conjugate type | amide |
| Linker | no |
| Small molecule | 4-(Chlorocarbonyl)-1,2-benzenedicarboxylic acid |
| Small molecule CAS | 53659-79-3 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -3.21500 |
| Rotatable bonds | 29 |
| H bond donor | 14 |
| H bond acceptor | 17 |
| Polar surface area (PSA) | 428.25000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation | 2017 | Profit, Adam A.; Vedad, Jayson; Desamero, Ruel Z. B. | Bioconjugate Chemistry | ||
