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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| PHWSY | (R)-5-oxo-2-pyrrolidinecarboxamide |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00074 |
| Smiles | |
| Inchi Key | InChIKey=ZZCDKOOIUGPOFO-JDOSAGNPSA-N |
| Molecular weight | 816.344 |
| Molecular formula | C40H48N8O11 |
| Chemical name | Peptide information |
| Sequence (one letter) | PHWSY |
| Length | 5 |
| Peptide name | pentapeptide, linear |
| External ID | |
|---|---|
| CAS number | 2230864-95-4 |
| Other information | |
|---|---|
| Application | Synthesis, tryptophan chemoselective beta?position conjugation |
| Additional function | Possible appications as protein labeling and various bioconjugations |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | no |
| Small molecule | (R)-5-oxo-2-pyrrolidinecarboxamide |
| Small molecule CAS | 118929-65-0 |
| Small molecule structure | |
| Structure method | NMR |
| Calculated properties | |
|---|---|
| LogP | -1.16319 |
| Rotatable bonds | 22 |
| H bond donor | 9 |
| H bond acceptor | 10 |
| Polar surface area (PSA) | 283.03000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation | 2018 | Yu, Younong; Zhang, Li-Kang; Buevich, Alexei V.; Li, Guoqing; Tang, Haiqun; Vachal, Petr; Colletti, Steven L.; Shi, Zhi-Cai | Journal of the American Chemical Society | ||
