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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| XASYQSL | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01514 |
| Smiles | |
| Molecular weight | 1348.57 |
| Molecular formula | C63H84N10O23 |
| Chemical name | Peptide information |
| Sequence (one letter) | XASYQSL |
| Length | 7 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 393836-36-7 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | Targeting, prostate cancer |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Structure method | RP-HPLC, FT/ICR/MS with ES |
| Calculated properties | |
|---|---|
| LogP | -4.75456 |
| Rotatable bonds | 32 |
| H bond donor | 18 |
| H bond acceptor | 24 |
| Polar surface area (PSA) | 542.65000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy | 2001 | Garsky, Victor M.; Lumma, Patricia K.; Feng, Dong-Mei; Wai, Jenny; Ramjit, Harri G.; Sardana, Mohinder K.; Oliff, Allen; Jones, Raymond E.; DeFeo-Jones, Deborah; Freidinger, Roger M. | Journal of Medicinal Chemistry | ||
