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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| XASXQSL | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01498 |
| Smiles | |
| Molecular weight | 1395.6 |
| Molecular formula | C65H89N9O25 |
| Chemical name | Peptide information |
| Sequence (one letter) | XASXQSL |
| Length | 7 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 207395-85-5 |
| Other information | |
|---|---|
| Application | Anticancer therapy, prostate targeting |
| Additional function | Clinical trials, safety and PK |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Calculated properties | |
|---|---|
| LogP | -3.28054 |
| Rotatable bonds | 31 |
| H bond donor | 17 |
| H bond acceptor | 25 |
| Polar surface area (PSA) | 545.14000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer | 2002 | DiPaola, Robert S.; Rinehart, John; Nemunaitis, John; Ebbinghaus, Scott; Rubin, Eric; Capanna, Terry; Ciardella, Marie; Doyle-Lindrud, Susan; Goodwin, Susan; Fontaine, Michelle; Adams, Ned; Williams, Adrienne; Schwartz, Michael; Winchell, Greg; Wickersham, Karen; Deutsch, Paul; Yao, Siu-Long | Journal of Clinical Oncology | ||
