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View Conjugates details

ConjuPepDB ID: cpd01476

Chemical structure


molecule
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cpd01476


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
XSSGQSSP Deacetylvinblastine
Identification
ConjuPepDB ID

cpd01476

Smiles
Molecular weight

1635.81

Molecular formula

C81H113N13O23

Chemical name
Peptide information
Sequence (one letter)

XSSGQSSP

Length

8

Peptide name

N/A

External ID
CAS number

301296-25-3

Other information
Application

Antitumor therapy

Additional function

Targeting, prostate cancer

Pharmacological class

anticancer

Conjugate type

ester

Linker

no

Small molecule

Deacetylvinblastine

Small molecule CAS

3352-69-0

Structure method

RP-HPLC, MS

Calculated properties
LogP

-4.30163

Rotatable bonds

32

H bond donor

15

H bond acceptor

23

Polar surface area (PSA)

513.56000

Citations
ID Title Year Authors Journal DOI

cpdart0228

Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity

2002

Brady, Stephen F.; Pawluczyk, Joseph M.; Lumma, Patricia K.; Feng, Dong-Mei; Wai, Jenny M.; Jones, Raymond; DeFeo-Jones, Deborah; Wong, Bradley K.; Miller-Stein, Cynthia; Lin, Jiunn H.; Oliff, Allen; Freidinger, Roger M.; Garsky, Victor M.

Journal of Medicinal Chemistry

..