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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| XRGD | butyric acid | Porfirin derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01396 |
| Smiles | |
| Molecular weight | 1744.65 |
| Molecular formula | C86H96N12O28 |
| Chemical name | Peptide information |
| Sequence (one letter) | XRGD |
| Length | 4 |
| Peptide name | tetrapeptide |
| External ID | |
|---|---|
| CAS number | 737765-76-3 |
| Other information | |
|---|---|
| Application | Anticancer therapy, photosensitizer |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | butyric acid |
| Small molecule | Porfirin derivative |
| Small molecule CAS | 219322-73-3 |
| Structure method | 1H- and 13C NMR, MS-MALDI |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | -4.40556 |
| Rotatable bonds | 26 |
| H bond donor | 24 |
| H bond acceptor | 33 |
| Polar surface area (PSA) | 646.73000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Efficient synthesis of RGD-containing cyclic peptide-porphyrin conjugates by ring-closing metathesis on solid support | 2004 | Chaleix, Vincent; Sol, Vincent; Guilloton, Michel; Granet, Robert; Krausz, Pierre | Tetrahedron Letters | ||
