Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.
3D model is for representation purpose only.
.
.
Schematic representation of peptide, linker and drug in the peptide-drug conjugates
 |
 |
 |
|
 |
|---|---|---|---|---|
| GPLG | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01288 |
| Smiles | |
| Molecular weight | 1089.42 |
| Molecular formula | C57H63N5O17 |
| Chemical name | Peptide information |
| Sequence (one letter) | GPLG |
| Length | 4 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 916686-30-1 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | Targeting, matrix metalloproteinases (MMPs) expressed from tumors |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Structure method | HPLC |
| Calculated properties | |
|---|---|
| LogP | 3.37137 |
| Rotatable bonds | 18 |
| H bond donor | 9 |
| H bond acceptor | 16 |
| Polar surface area (PSA) | 325.99000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Peptide-doxorubicin conjugates specifically degraded by matrix metalloproteinases expressed from tumor | 2006 | Lee, Gee Young; Song, Ji-hye; Kim, Sang Yoon; Park, Kyeongsoon; Byun, Youngro | Drug Development Research | ||
