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View Conjugates details

ConjuPepDB ID: cpd01248

Chemical structure


molecule
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cpd01248


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
CVKRGLKLRHVRPRVTRMDV 4-maleimidobutyric acid Doxorubicin
Identification
ConjuPepDB ID

cpd01248

Smiles
Molecular weight

3126.62

Molecular formula

C138H223N41O38S2

Chemical name
Peptide information
Sequence (one letter)

CVKRGLKLRHVRPRVTRMDV

Length

20

Peptide name

N/A

External ID
CAS number

916443-75-9

Other information
Application

Antitumor therapy, colon and breast tumors

Additional function

improved efficacy and circumventing resistance

Pharmacological class

anticancer

Conjugate type

sulfide

Linker

N/A

Linker Type

4-maleimidobutyric acid

Small molecule

Doxorubicin

Small molecule CAS

23214-92-8

Structure method

1H NMR, HPLC

NMR solvent

DMSO-d6

Calculated properties
LogP

-13.64516

Rotatable bonds

96

H bond donor

45

H bond acceptor

57

Polar surface area (PSA)

1304.70000

Citations
ID Title Year Authors Journal DOI

cpdart0189

Improved Therapeutic Efficacy of Doxorubicin through Conjugation with a Novel Peptide Drug Delivery Technology (Vectocell)

2006

Meyer-Losic, Florence; Quinonero, Jerome; Dubois, Vincent; Alluis, Bertrand; Dechambre, Mireille; Michel, Matthieu; Cailler, Francoise; Fernandez, Anne-Marie; Trouet, Andre; Kearsey, Jonathan

Journal of Medicinal Chemistry

..