3D model is for representation purpose only.
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RLNF | 1-(1-Methylethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carboxylic acid |
Identification | |
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ConjuPepDB ID | cpd01229 |
Smiles | |
Molecular weight | 819.38 |
Molecular formula | C37H49F4N11O6 |
Chemical name | Peptide information |
Sequence (one letter) | RLNF |
Length | 4 |
Peptide name | tetrapeptide |
External ID | |
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CAS number | 851456-31-0 |
Other information | |
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Application | Anticancer therapy, DNA replication |
Additional function | inhibition of cyclin-dependent kinase 2 (CDK2) / cyclin A substrate reruitment |
Pharmacological class | anticancer |
Conjugate type | amide |
Linker | no |
Small molecule | 1-(1-Methylethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carboxylic acid |
Small molecule CAS | 306935-42-2 |
Structure method | 1H NMR, HPLC |
Calculated properties | |
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LogP | 0.36299 |
Rotatable bonds | 21 |
H bond donor | 9 |
H bond acceptor | 10 |
Polar surface area (PSA) | 282.30000 |
Citations | |||||
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ID | Title | Year | Authors | Journal | DOI |
REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors | 2006 | Andrews, Martin J. I.; Kontopidis, George; McInnes, Campbell; Plater, Andy; Innes, Lorraine; Cowan, Angela; Jewsbury, Philip; Fischer, Peter M. | ChemBioChem |