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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RGDS | Estradiol-3-carboxymethyl ether |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01141 |
| Smiles | |
| Molecular weight | 1060.49 |
| Molecular formula | C56H68N8O13 |
| Chemical name | Peptide information |
| Sequence (one letter) | RGDS |
| Length | 4 |
| Peptide name | tetrapeptide |
| External ID | |
|---|---|
| CAS number | 946144-06-5 |
| Other information | |
|---|---|
| Application | Osteoporosis therapy, estrogen replacement |
| Additional function | improved potency and reduced side effects |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Estradiol-3-carboxymethyl ether |
| Small molecule CAS | 41164-36-7 |
| Structure method | 1H NMR |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | 4.35274 |
| Rotatable bonds | 28 |
| H bond donor | 8 |
| H bond acceptor | 14 |
| Polar surface area (PSA) | 298.74000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Improved anti-osteoporosis potency and reduced endometrial membrane hyperplasia during hormone replacement therapy with estrogen-RGD peptide conjugates | 2007 | Xiong, Yu; Zhao, Ming; Wang, Chao; Chang, Heng Wei; Peng, Shiqi | Journal of Medicinal Chemistry | ||
