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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| KXCKXC | Paclitaxel derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01117 |
| Smiles | |
| Molecular weight | 2478 |
| Molecular formula | C126H155N11O37S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | KXCKXC |
| Length | 6 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 960500-32-7 |
| Other information | |
|---|---|
| Application | Antitumor therapy, cervical and prostate human cancer |
| Additional function | improved biological activity |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | no |
| Small molecule | Paclitaxel derivative |
| Small molecule CAS | 152565-19-0 |
| Structure method | HPLC, ESI-MS |
| Calculated properties | |
|---|---|
| LogP | 3.68384 |
| Rotatable bonds | 60 |
| H bond donor | 15 |
| H bond acceptor | 29 |
| Polar surface area (PSA) | 724.45000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and antitumor activity of peptide-paclitaxel conjugates | 2007 | Papas, Serafim; Akoumianaki, Tonia; Kalogiros, Christos; Hadjiarapoglou, Lazaros; Theodoropoulos, Panayiotis A.; Tsikaris, Vassilios | Journal of Peptide Science | ||
