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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| WTGWCLNPEESTWGFCTGSF | Paclitaxel succinate |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01106 |
| Smiles | |
| Molecular weight | 3319.34 |
| Molecular formula | C163H198N26O46S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | WTGWCLNPEESTWGFCTGSF |
| Length | 20 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1000203-49-5 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Antitumor therapy and targeting |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Paclitaxel succinate |
| Small molecule CAS | 117527-50-1 |
| Structure method | RP-HPLC |
| Calculated properties | |
|---|---|
| LogP | -3.93515 |
| Rotatable bonds | 68 |
| H bond donor | 32 |
| H bond acceptor | 39 |
| Polar surface area (PSA) | 1087.87000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Design and synthesis of paclitaxel conjugated with an ErbB2-recognizing peptide, EC-1 | 2007 | Li, Peng; Jiang, Sheng; Pero, Stephanie C.; Oligino, Lyn; Krag, David N.; Michejda, Christopher J.; Roller, Peter P. | Biopolymers | ||
