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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GRKKRRQRRRPPQ | PEG | N-[2-[2-oxo-2-[[4-(10,15,20-triphenyl-21H,23H-porphin-5-yl)phenyl]amino]ethoxy]acetyl]-L-Aspartic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01077 |
| Smiles | |
| Molecular weight | 2766.49 |
| Molecular formula | C132H191N41O26 |
| Chemical name | Peptide information |
| Sequence (one letter) | GRKKRRQRRRPPQ |
| Length | 13 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1067653-17-1 |
| Other information | |
|---|---|
| Application | Anicancer therapy, prostate |
| Additional function | targeting |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | PEG |
| Small molecule | N-[2-[2-oxo-2-[[4-(10,15,20-triphenyl-21H,23H-porphin-5-yl)phenyl]amino]ethoxy]acetyl]-L-Aspartic acid |
| Small molecule CAS | 1067653-28-4 |
| Structure method | 1H and 13C NMR and HPLC |
| NMR solvent | CDCL3 |
| Calculated properties | |
|---|---|
| LogP | -8.81898 |
| Rotatable bonds | 91 |
| H bond donor | 38 |
| H bond acceptor | 48 |
| Polar surface area (PSA) | 1087.81000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Photoinduced Cytotoxicity and Biodistribution of Prostate Cancer Cell-Targeted Porphyrins | 2008 | Sehgal, Inder; Sibrian-Vazquez, Martha; Vicente, M. Graca H. | Journal of Medicinal Chemistry | ||
