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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RRRR | succinic acid | Daunorubicine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01074 |
| Smiles | |
| Molecular weight | 1250.62 |
| Molecular formula | C55H82N18O16 |
| Chemical name | Peptide information |
| Sequence (one letter) | RRRR |
| Length | 4 |
| Peptide name | polyarginin |
| External ID | |
|---|---|
| CAS number | 1009811-77-1 |
| Other information | |
|---|---|
| Application | Anticancer therapy, leukemia |
| Additional function | increased cellular uptake |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | succinic acid |
| Small molecule | Daunorubicine |
| Small molecule CAS | 20830-81-3 |
| Structure method | 1H NMR and RP-HPLC |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | -5.50630 |
| Rotatable bonds | 32 |
| H bond donor | 22 |
| H bond acceptor | 28 |
| Polar surface area (PSA) | 596.01000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60) | 2008 | Banoczi, Zoltan; Peregi, Balazs; Orban, Erika; Szabo, Rita; Hudecz, Ferenc | ARKIVOC | ||
