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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RRRRRRRR | succinic acid | Daunorubicine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01072 |
| Smiles | |
| Molecular weight | 1875.02 |
| Molecular formula | C79H130N34O20 |
| Chemical name | Peptide information |
| Sequence (one letter) | RRRRRRRR |
| Length | 8 |
| Peptide name | polyarginin |
| External ID | |
|---|---|
| CAS number | 1009811-79-3 |
| Other information | |
|---|---|
| Application | Anticancer therapy, leukemia |
| Additional function | increased cellular uptake |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | succinic acid |
| Small molecule | Daunorubicine |
| Small molecule CAS | 20830-81-3 |
| Structure method | 1H NMR and RP-HPLC |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | -10.41588 |
| Rotatable bonds | 56 |
| H bond donor | 38 |
| H bond acceptor | 44 |
| Polar surface area (PSA) | 960.01000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60) | 2008 | Banoczi, Zoltan; Peregi, Balazs; Orban, Erika; Szabo, Rita; Hudecz, Ferenc | ARKIVOC | ||
