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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| PI | Vinblastine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01059 |
| Smiles | |
| Molecular weight | 1047.54 |
| Molecular formula | C58H75N6O12 |
| Chemical name | Peptide information |
| Sequence (one letter) | PI |
| Length | 2 |
| Peptide name | dipeptide |
| External ID | |
|---|---|
| CAS number | 1097833-57-2 |
| Other information | |
|---|---|
| Application | Anticancer, antimitotic |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Vinblastine |
| Small molecule CAS | 865-21-4 |
| Small molecule structure | |
| Structure method | 1H and 13C NMR, COSY |
| NMR solvent | CDCl5 |
| Calculated properties | |
|---|---|
| LogP | -1.28107 |
| Rotatable bonds | 17 |
| H bond donor | 4 |
| H bond acceptor | 11 |
| Polar surface area (PSA) | 217.34000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and Biological Evaluation of Vinca Alkaloids and Phomopsin Hybrids | 2009 | Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guenard, Daniel; Gueritte, Francoise | Journal of Medicinal Chemistry | ||
