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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| KHAIYPRH | aminobenzoic acid | Artemisinin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01055 |
| Smiles | |
| Molecular weight | 2112.05 |
| Molecular formula | C109H141N21O23 |
| Chemical name | Peptide information |
| Sequence (one letter) | KHAIYPRH |
| Length | 8 |
| Peptide name | Transferrin receptor binding peptide |
| External ID | |
|---|---|
| CAS number | 1155231-83-6 |
| Other information | |
|---|---|
| Application | Anticancer, leukemia |
| Additional function | transferrin-receptor targeting |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | aminobenzoic acid |
| Small molecule | Artemisinin |
| Small molecule CAS | 63968-64-9 |
| Small molecule structure | |
| Structure method | 1H NMR. HPLC |
| Calculated properties | |
|---|---|
| LogP | 6.44027 |
| Rotatable bonds | 46 |
| H bond donor | 17 |
| H bond acceptor | 30 |
| Polar surface area (PSA) | 610.91000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide | 2009 | Oh, Steve; Kim, Byung Ju; Singh, Narendra P.; Lai, Henry; Sasaki, Tomikazu | Cancer Letters | ||
