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ConjuPepDB ID: cpd01034

Chemical structure


molecule
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cpd01034


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
SSFY Cyclophosphamide
Identification
ConjuPepDB ID

cpd01034

Smiles
Molecular weight

893.268

Molecular formula

C39H50Cl2N7O11P

Chemical name
Peptide information
Sequence (one letter)

SSFY

Length

4

Peptide name

tetrapeptide

External ID
CAS number

1161754-69-3

Other information
Application

Anticancer therapy, prostate cancer

Additional function

targeting prostate cancer (prodrug)

Pharmacological class

anticancer

Conjugate type

amide

Linker

no

Small molecule

Cyclophosphamide

Small molecule CAS

50-18-0

Small molecule structure

Structure method

1H and 31P NMR

Calculated properties
LogP

0.76759

Rotatable bonds

23

H bond donor

9

H bond acceptor

9

Polar surface area (PSA)

256.99000

Citations
ID Title Year Authors Journal DOI

cpdart0153

Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA)

2009

Jiang, Yongying; Di Paola, Robert S.; Hu, Longqin

Bioorganic & Medicinal Chemistry

..