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View Conjugates details

ConjuPepDB ID: cpd00998

Chemical structure


molecule
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cpd00998


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
EGFLG Methotrexate
Identification
ConjuPepDB ID

cpd00998

Smiles
Molecular weight

1044.55

Molecular formula

C50H72N14O11

Chemical name
Peptide information
Sequence (one letter)

EGFLG

Length

5

Peptide name

N/A

External ID
CAS number

864282-42-8

Other information
Application

Osteoarthritis

Additional function

Synovial fluid viscoelasticity and lubricating effect

Pharmacological class

Anti-inflammatory

Conjugate type

amide

Linker

no

Small molecule

Methotrexate

Small molecule CAS

59-05-2

Small molecule structure

Structure method

1H NMR, HPLC

Calculated properties
LogP

-1.63067

Rotatable bonds

35

H bond donor

9

H bond acceptor

18

Polar surface area (PSA)

361.45000

Citations
ID Title Year Authors Journal DOI

cpdart0148

Novel hyaluronic acid-methotrexate conjugates for osteoarthritis treatment

2009

Homma, Akie; Sato, Haruhiko; Okamachi, Akira; Emura, Takashi; Ishizawa, Takenori; Kato, Tatsuya; Matsuura, Tetsu; Sato, Shigeo; Tamura, Tatsuya; Higuchi, Yoshinobu; Watanabe, Tomoyuki; Kitamura, Hidetomo; Asanuma, Kentaro; Yamazaki, Tadao; Ikemi, Masahisa; Kitagawa, Hironoshin; Morikawa, Tadashi; Ikeya, Hitoshi; Maeda, Kazuaki; Takahashi, Koichi; Nohmi, Kenji; Izutani, Noriyuki; Kanda, Makoto; Suzuki, Ryochi

Bioorganic & Medicinal Chemistry

..