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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| XRRRRRRRR | glutamic acid | (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(1-hydrazonoethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-Naphthacenedione |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00960 |
| Smiles | |
| Molecular weight | 1918.07 |
| Molecular formula | C80H135N37O19 |
| Chemical name | Peptide information |
| Sequence (one letter) | XRRRRRRRR |
| Length | 9 |
| Peptide name | octarginin |
| External ID | |
|---|---|
| CAS number | 1204583-20-9 |
| Other information | |
|---|---|
| Application | Anticancer therapy, leukemia and hepatoma |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glutamic acid |
| Small molecule | (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(1-hydrazonoethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-Naphthacenedione |
| Small molecule CAS | 189329-51-9 |
| Structure method | RP-HPLC and MS |
| Calculated properties | |
|---|---|
| LogP | -11.34490 |
| Rotatable bonds | 57 |
| H bond donor | 40 |
| H bond acceptor | 46 |
| Polar surface area (PSA) | 1007.34000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
New daunomycin–oligoarginine conjugates: Synthesis, characterization, and effect on human leukemia and human hepatoma cells | 2009 | Zsanett Miklán; Erika Orbán; Gabriella Csík; Gitta Schlosser; Anna Magyar; Ferenc Hudecz | Peptide Science | ||
