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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GRERK | 2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00948 |
| Smiles | |
| Inchi Key | InChIKey=WMBLWFAOWHLHBG-VEGQPAGDSA-N |
| Molecular weight | 1304.65 |
| Molecular formula | C60H96N12O16S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | GRERK |
| Length | 5 |
| Peptide name | Glu-AQ |
| External ID | |
|---|---|
| CAS number | 1239603-93-0 |
| Other information | |
|---|---|
| Application | Synthesis and DNA nuclease activity |
| Additional function | DNA cleavage, metal-free |
| Conjugate type | sulfonamide |
| Linker | no |
| Small molecule | 2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonamide |
| Small molecule CAS | 378230-81-0 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | 1.83800 |
| Rotatable bonds | 31 |
| H bond donor | 11 |
| H bond acceptor | 19 |
| Polar surface area (PSA) | 431.91000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
A Metal-Free DNA Nuclease Based on a Cyclic Peptide Scaffold | 2010 | Alkhader, Shadad; Ezra, Aviva; Kasparkova, Jana; Brabec, Viktor; Yavin, Eylon | Bioconjugate Chemistry | ||
