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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| XRKKRRQRRR | triazole | alkyne-functionalized cysteine protease inhibitor L1 |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00927 |
| Smiles | |
| Inchi Key | InChIKey=VXZREZGWYRYSFH-ZJQPJSICSA-N |
| Molecular weight | 1839.09 |
| Molecular formula | C79H134N38O14 |
| Chemical name | Peptide information |
| Sequence (one letter) | XRKKRRQRRR |
| Length | 10 |
| Peptide name | Tat (lysosome delivery) |
| External ID | |
|---|---|
| CAS number | 1258942-80-1 |
| Other information | |
|---|---|
| Application | Synthesis and inhibition of lysosomal cysteine proteases |
| Additional function | Potential improvement of in vivo drug efficacy |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | triazole |
| Small molecule | alkyne-functionalized cysteine protease inhibitor L1 |
| Small molecule CAS | 1258942-76-5 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -11.12845 |
| Rotatable bonds | 66 |
| H bond donor | 26 |
| H bond acceptor | 38 |
| Polar surface area (PSA) | 902.90000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
"Click" synthesis of small molecule-peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases" | 2010 | Loh, Yuhui; Shi, Haibin; Hu, Mingyu; Yao, Shao Q. | Chemical Communications | ||
