conjupepdb_log

View Conjugates details

ConjuPepDB ID: cpd00920

Chemical structure


molecule
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cpd00920


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
EVNXVAEFXD PEG Cholestanol
Identification
ConjuPepDB ID

cpd00920

Smiles
Inchi Key

InChIKey=LFXKCKMAXYNSBS-FLWARNLKSA-N

Molecular weight

1695.04

Molecular formula

C86H142N12O22

Chemical name
Peptide information
Sequence (one letter)

EVNXVAEFXD

Length

10

Peptide name

oligopeptide

External ID
CAS number

1268472-45-2

Other information
Application

Alzheimer’s disease therapy, beta-secretase inhibition

Conjugate type

amide

Linker

N/A

Linker Type

PEG

Small molecule

Cholestanol

Small molecule CAS

80-97-7

Small molecule structure

Structure method

1H and 13C NMR, COSY, HMBC, HSQC, ROESY

NMR solvent

CDCl3 or CD3OD

Calculated properties
LogP

0.25966

Rotatable bonds

57

H bond donor

15

H bond acceptor

22

Polar surface area (PSA)

532.15000

Citations
ID Title Year Authors Journal DOI

Cpdart0129

Structural Design, Solid‐Phase Synthesis and Activity of Membrane‐Anchored β‐Secretase Inhibitors on Aβ Generation from Wild‐Type and Swedish‐Mutant APP

2010

Schieb, Heinke; Weidlich, Sebastian; Schlechtingen, Georg; Linning, Philipp; Jennings, Gary; Gruner, Margit; Wiltfang, Jens; Klafki, Hans-Wolfgang; Knoelker, Hans-Joachim

Chemistry - A European Journal

..