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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| WRRRRRRRR | Deacetylvinblastine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00870 |
| Smiles | |
| Inchi Key | InChIKey=YCIGAVLAWOEGPB-HQMJHNPNSA-N |
| Molecular weight | 2189.28 |
| Molecular formula | C102H160N38O17 |
| Chemical name | Peptide information |
| Sequence (one letter) | WRRRRRRRR |
| Length | 9 |
| Peptide name | polyarginine |
| External ID | |
|---|---|
| CAS number | 1256091-95-8 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | Improve cell penetration |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Deacetylvinblastine |
| Small molecule CAS | 3352-69-0 |
| Small molecule structure | |
| Structure method | 1H, 2D-GHSQCAD, GCOSY, 2D-GHMBCAD, and 2D-ROESY |
| Calculated properties | |
|---|---|
| LogP | -7.19084 |
| Rotatable bonds | 59 |
| H bond donor | 31 |
| H bond acceptor | 43 |
| Polar surface area (PSA) | 951.92000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and in Vitro Antitumor Effect of Vinblastine Derivative-Oligoarginine Conjugates | 2010 | Banoczi, Zoltan; Gorka-Kereskenyi, Almos; Remenyi, Judit; Orban, Erika; Hazai, Laszlo; Tokesi, Natalia; Olah, Judit; Ovadi, Judit; Beni, Zoltan; Hada, Viktor; Szantay, Csaba Jr.; Hudecz, Ferenc; Kalaus, Gyorgy; Szantay, Csaba | Bioconjugate Chemistry | ||
