conjupepdb_log

View Conjugates details

ConjuPepDB ID: cpd00831

Chemical structure


molecule
3D viewer Help Icon Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.

3D model is for representation purpose only.

cpd00831


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
RPKT 1,4-dihydroxyanthraquinone (quinizarin) derivative
Identification
ConjuPepDB ID

cpd00831

Smiles
Inchi Key

InChIKey=XUHLCMVXISUNGB-NMIDTGSNSA-N

Molecular weight

722.339

Molecular formula

C35H46N8O9

Chemical name
Peptide information
Sequence (one letter)

RPKT

Length

4

Peptide name

tuftsin (liberated from the Fc domain of the heavy chain of IgG

External ID
CAS number

1283096-47-8

Other information
Application

Anticancer therapy, A549 and HL-60 cells)

Additional function

Increase activity and specific toxicity

Conjugate type

amide

Linker

no

Small molecule

1,4-dihydroxyanthraquinone (quinizarin) derivative

Small molecule CAS

81-64-1

Small molecule structure

Structure method

1H-NMR

Calculated properties
LogP

-2.67889

Rotatable bonds

17

H bond donor

9

H bond acceptor

14

Polar surface area (PSA)

292.86000

Citations
ID Title Year Authors Journal DOI

Cpdart0121

Solid phase synthesis and biological activity of tuftsin conjugates

2011

Kukowska-Kaszuba, Magdalena; Dzierzbicka, Krystyna; Serocki, Marcin; Skladanowski, Andrzej

Journal of Medicinal Chemistry

..