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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| TKPR | acridone-4-carboxylic acid (4-carboxyacridone) derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00816 |
| Smiles | |
| Inchi Key | InChIKey=NTYRTWAQOIRHSM-AVRDBVGKSA-N |
| Molecular weight | 778.376 |
| Molecular formula | C37H50N10O9 |
| Chemical name | Peptide information |
| Sequence (one letter) | TKPR |
| Length | 4 |
| Peptide name | tuftsin (liberated from the Fc domain of the heavy chain of IgG |
| External ID | |
|---|---|
| CAS number | 1283096-62-7 |
| Other information | |
|---|---|
| Application | Anticancer therapy, A549 and HL-60 cells) |
| Additional function | Increase activity and specific toxicity |
| Conjugate type | amide |
| Linker | no |
| Small molecule | acridone-4-carboxylic acid (4-carboxyacridone) derivative |
| Small molecule CAS | 24782-64-7 |
| Small molecule structure | |
| Structure method | 1H-NMR |
| Calculated properties | |
|---|---|
| LogP | -2.52514 |
| Rotatable bonds | 19 |
| H bond donor | 10 |
| H bond acceptor | 14 |
| Polar surface area (PSA) | 313.76000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Solid phase synthesis and biological activity of tuftsin conjugates | 2011 | Kukowska-Kaszuba, Magdalena; Dzierzbicka, Krystyna; Serocki, Marcin; Skladanowski, Andrzej | Journal of Medicinal Chemistry | ||
