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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GEGFPGVGVPGVGFPGFGFPGVGVPGVGFP | 3-(4-piperidyl)-6-fluoro-1,2-benzisoxazole |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00734 |
| Smiles | |
| Inchi Key | InChIKey=OUZNENVARNPABX-OEMJBEGNSA-N |
| Molecular weight | 3127.6 |
| Molecular formula | C157H215FN32O35 |
| Chemical name | Peptide information |
| Sequence (one letter) | GEGFPGVGVPGVGFPGFGFPGVGVPGVGFP |
| Length | 30 |
| Peptide name | elastin (fragment) |
| External ID | |
|---|---|
| CAS number | 1270202-40-8 |
| Other information | |
|---|---|
| Application | Antomicrobial therapy, antibacterial (C. staphylococcus, K. pneumoniae) and antifungal (A. niger, A. flavus and F. oxysporum) |
| Additional function | Increase effect and enhance biocompatibility |
| Conjugate type | amide |
| Linker | no |
| Small molecule | 3-(4-piperidyl)-6-fluoro-1,2-benzisoxazole |
| Small molecule CAS | 84163-13-3 |
| Small molecule structure | |
| Structure method | 1H-NMR |
| NMR solvent | CDCl3 |
| Calculated properties | |
|---|---|
| LogP | -3.06862 |
| Rotatable bonds | 78 |
| H bond donor | 24 |
| H bond acceptor | 33 |
| Polar surface area (PSA) | 902.13000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials - A novel approach to enhance biocompatibility | 2011 | Suhas, R.; Chandrashekar, S.; Gowda, D. Channe | European Journal of Medicinal Chemistry | ||
