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View Conjugates details

ConjuPepDB ID: cpd00719

Chemical structure


molecule
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cpd00719


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
CMYIEALDKYAC glutaric acid Fmoc-protected doxorubicine
Identification
ConjuPepDB ID

cpd00719

Smiles
Inchi Key

InChIKey=AUVXSKLJGQSYOR-MBHWYACESA-N

Molecular weight

2504.93

Molecular formula

C124H148N14O36S3

Chemical name
Peptide information
Sequence (one letter)

CMYIEALDKYAC

Length

12

Peptide name

EGFR-binding peptide (EBP)

External ID
CAS number

1268633-57-3

Other information
Application

Anticancer therapy, SW480, SGC-7901, MCF-8

Additional function

Targeting EGFR overexpressing tumor cells, enhance efficacy and reduce systemic toxicity

Conjugate type

amide

Linker

N/A

Linker Type

glutaric acid

Small molecule

Fmoc-protected doxorubicine

Small molecule CAS

136582-53-1

Small molecule structure

Structure method

NMR

Calculated properties
LogP

7.93792

Rotatable bonds

65

H bond donor

25

H bond acceptor

33

Polar surface area (PSA)

764.34000

Citations
ID Title Year Authors Journal DOI

Cpdart0112

Biological Evaluation of a Novel Doxorubicin-Peptide Conjugate for Targeted Delivery to EGF Receptor-Overexpressing Tumor Cells

2011

Ai, Shibin; Duan, Jianli; Liu, Xin; Bock, Stephanie; Tian, Yuan; Huang, Zebo

Molecular Pharmaceutics

..