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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| TKPKGTKPKGTKPKGTKPKG | glutaric acid | coumarone derivative TB5, antitubercular drug |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00640 |
| Smiles | |
| Inchi Key | InChIKey=DFJDYLAVKDMPER-WPGCPPPASA-N |
| Molecular weight | 2595.48 |
| Molecular formula | C122H198N30O32 |
| Chemical name | Peptide information |
| Sequence (one letter) | TKPKGTKPKGTKPKGTKPKG |
| Length | 20 |
| Peptide name | OT20 tuftsin |
| External ID | |
|---|---|
| CAS number | 1373532-04-7 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy, anti-tuberculotic |
| Additional function | Targeting GranF2 and OT20, enhance cellular uptake, overcome drug resistance |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glutaric acid |
| Small molecule | coumarone derivative TB5, antitubercular drug |
| Small molecule CAS | 899387-20-3 |
| Small molecule structure | |
| Structure method | 1H- and 13C-NMR |
| Calculated properties | |
|---|---|
| LogP | -15.05802 |
| Rotatable bonds | 85 |
| H bond donor | 30 |
| H bond acceptor | 41 |
| Polar surface area (PSA) | 961.76000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Enhanced Cellular Uptake of a New, in Silico Identified Antitubercular Candidate by Peptide Conjugation | 2012 | Horvati, Kata; Bacsa, Bernadett; Szabo, Nora; David, Sandor; Mezo, Gabor; Grolmusz, Vince; Vertessy, Beata; Hudecz, Ferenc; Bosze, Szilvia | Bioconjugate Chemistry | ||
