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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RRRRRHHHHHC | sulfide | Cholesterol |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00534 |
| Smiles | |
| Inchi Key | InChIKey=IWWQJFPOHLKPBZ-LOAQRCQDSA-N |
| Molecular weight | 2027.19 |
| Molecular formula | C93H150N36O14S |
| Chemical name | Peptide information |
| Sequence (one letter) | RRRRRHHHHHC |
| Length | 11 |
| Peptide name | polyarginine |
| External ID | |
|---|---|
| CAS number | 1566560-81-3 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Self-assembly, promising gene delivery carrier for intravenous therapy |
| Pharmacological class | other |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | sulfide |
| Small molecule | Cholesterol |
| Small molecule CAS | 57-88-5 |
| Small molecule structure | |
| Structure method | 1H- and 13C-NMR |
| NMR solvent | CDCl3 |
| Calculated properties | |
|---|---|
| LogP | -8.95026 |
| Rotatable bonds | 63 |
| H bond donor | 27 |
| H bond acceptor | 34 |
| Polar surface area (PSA) | 846.02000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Cholesterol-peptide hybrids to form liposome-like vesicles for gene delivery | 2013 | Tang, Qiong; Cao, Bin; Wu, Haiyan; Cheng, Gang | PLoS One | ||
