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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GFLG | 3-Maleimidopropionic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00525 |
| Smiles | |
| Inchi Key | InChIKey=IQUCPPQTLGEQEK-OALUTQOASA-N |
| Molecular weight | 543.233 |
| Molecular formula | C26H33N5O8 |
| Chemical name | Peptide information |
| Sequence (one letter) | GFLG |
| Length | 4 |
| Peptide name | enzyme-cleavable peptidic linker |
| External ID | |
|---|---|
| CAS number | 1427500-04-6 |
| Other information | |
|---|---|
| Application | Anticancer therapy, KB-3-1 and KB-V1 cells |
| Additional function | Improved cellular uptake and toxicity, overcome drug resistance |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | 3-Maleimidopropionic acid |
| Small molecule CAS | 7423-55-4 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -1.07040 |
| Rotatable bonds | 15 |
| H bond donor | 5 |
| H bond acceptor | 8 |
| Polar surface area (PSA) | 191.08000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Cellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation site | 2013 | Zhang, Pengcheng; Cheetham, Andrew G.; Lock, Lye Lin; Cui, Honggang | Bioconjugate Chemistry | ||
