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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GTRSSRAGLQFPVGRVHRLLRK | Porphyrin derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00445 |
| Smiles | |
| Inchi Key | InChIKey=PJJPGKKHGBRJNE-AJXIGLCWSA-N |
| Molecular weight | 3130.68 |
| Molecular formula | C153H215N45O28 |
| Chemical name | Peptide information |
| Sequence (one letter) | GTRSSRAGLQFPVGRVHRLLRK |
| Length | 22 |
| Peptide name | cationic antimicrobial peptides (CAMP) |
| External ID | |
|---|---|
| CAS number | 1541183-49-6 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy. photodynamic antibacterial (Gram-negative E. coli) |
| Additional function | Potential to carry drugs and other types of cargo inside mammalian cells similar to cell-penetrating peptides |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Porphyrin derivative |
| Small molecule CAS | 497064-95-6 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -7.01630 |
| Rotatable bonds | 90 |
| H bond donor | 40 |
| H bond acceptor | 47 |
| Polar surface area (PSA) | 1206.55000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis, Spectroscopic, and Photophysical Characterization and Photosensitizing Activity toward Prokaryotic and Eukaryotic Cells of Porphyrin-Magainin and -Buforin Conjugates | 2014 | Dosselli, Ryan; Ruiz-Gonzalez, Ruben; Moret, Francesca; Agnolon, Valentina; Compagnin, Chiara; Mognato, Maddalena; Sella, Valentina; Agut, Montserrat; Nonell, Santi; Gobbo, Marina; Reddi, Elena | Journal of Medicinal Chemistry | ||
