Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.
3D model is for representation purpose only.
.
.
Schematic representation of peptide, linker and drug in the peptide-drug conjugates
 |
 |
 |
|
 |
|---|---|---|---|---|
| GGGPKKKRKVGG | butane | telithromycin (TEL) derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00368 |
| Smiles | |
| Inchi Key | InChIKey=CBDAGLGUGYSECD-JQEYCXTNSA-N |
| Molecular weight | 1970.2 |
| Molecular formula | C91H159N25O23 |
| Chemical name | Peptide information |
| Sequence (one letter) | GGGPKKKRKVGG |
| Length | 12 |
| Peptide name | designed oligopeptides |
| External ID | |
|---|---|
| CAS number | 1629893-88-4 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Probes for interrogating nascent peptide-exit tunnel interaction from the PTC to the exit tunnel entrance |
| Pharmacological class | other |
| Conjugate type | triazole |
| Linker | N/A |
| Linker Type | butane |
| Small molecule | telithromycin (TEL) derivative |
| Small molecule CAS | 849407-75-6 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -6.66246 |
| Rotatable bonds | 58 |
| H bond donor | 19 |
| H bond acceptor | 31 |
| Polar surface area (PSA) | 723.83000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome | 2014 | Washington, Arren Z.; Benicewicz, Derek B.; Canzoneri, Joshua C.; Fagan, Crystal E.; Mwakwari, Sandra C.; Maehigashi, Tatsuya; Dunham, Christine M.; Oyelere, Adegboyega K. | ACS Chemical Biology | ||
