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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RGDRGDRGDRGDPGA | butane | telithromycin (TEL) derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00364 |
| Smiles | |
| Inchi Key | InChIKey=ZFKBITZTTVEBED-RNYUGHESSA-N |
| Molecular weight | 2288.16 |
| Molecular formula | C95H157N33O33 |
| Chemical name | Peptide information |
| Sequence (one letter) | RGDRGDRGDRGDPGA |
| Length | 15 |
| Peptide name | designed oligopeptides |
| External ID | |
|---|---|
| CAS number | 1629893-92-0 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Probes for interrogating nascent peptide-exit tunnel interaction from the PTC to the exit tunnel entrance |
| Pharmacological class | other |
| Conjugate type | triazole |
| Linker | N/A |
| Linker Type | butane |
| Small molecule | telithromycin (TEL) derivative |
| Small molecule CAS | 849407-75-6 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -20.26502 |
| Rotatable bonds | 64 |
| H bond donor | 28 |
| H bond acceptor | 47 |
| Polar surface area (PSA) | 1046.37000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome | 2014 | Washington, Arren Z.; Benicewicz, Derek B.; Canzoneri, Joshua C.; Fagan, Crystal E.; Mwakwari, Sandra C.; Maehigashi, Tatsuya; Dunham, Christine M.; Oyelere, Adegboyega K. | ACS Chemical Biology | ||
