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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| XLIVAGK | triazole | Oxaliplatin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00358 |
| Smiles | |
| Inchi Key | InChIKey=BUYHDLJWEDLBAN-BKAJIVOUSA-L |
| Molecular weight | 1158.55 |
| Molecular formula | C44H77N13O9[O-]2[Pt+2] |
| Chemical name | Peptide information |
| Sequence (one letter) | XLIVAGK |
| Length | 7 |
| Peptide name | hexapeptide |
| External ID | |
|---|---|
| CAS number | 1616793-07-7 |
| Other information | |
|---|---|
| Application | Anticancer therapy, breast cancer |
| Additional function | Localization, lower systemic toxicity |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | triazole |
| Small molecule | Oxaliplatin |
| Small molecule CAS | 61825-94-3 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -9.79083 |
| Rotatable bonds | 26 |
| H bond donor | 10 |
| H bond acceptor | 14 |
| Polar surface area (PSA) | 360.24000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy | 2014 | Reithofer, Michael R.; Chan, Kiat-Hwa; Lakshmanan, Anupama; Lam, Dang Hoang; Mishra, Archana; Gopalan, Began; Joshi, Mangesh; Wang, Shu; Hauser, Charlotte A. E. | Chemical Science | ||
