conjupepdb_log

View Conjugates details

ConjuPepDB ID: cpd00325

Chemical structure


molecule
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cpd00325


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
EEEE Naproxen
Identification
ConjuPepDB ID

cpd00325

Smiles
Inchi Key

InChIKey=XQPGXUVLXWEVCS-QAMDWANKSA-N

Molecular weight

746.265

Molecular formula

C34H42N4O15

Chemical name
Peptide information
Sequence (one letter)

EEEE

Length

4

Peptide name

glutamic acid oligopeptide

External ID
CAS number

1966935-11-4

Other information
Application

Synthesis,peptide-NSAID conjugates prodrugs, preliminary studies for hydroxyapatite binding

Additional function

Bone targeting drugs delivery

Pharmacological class

anti-inflammatoric

Conjugate type

amide

Linker

no

Small molecule

Naproxen

Small molecule CAS

22204-53-1

Small molecule structure

Calculated properties
LogP

-0.57289

Rotatable bonds

23

H bond donor

9

H bond acceptor

15

Polar surface area (PSA)

312.13000

Citations
ID Title Year Authors Journal DOI

Cpdart0064

Synthesis and Preliminary Evaluation of Novel Bone-targeting NSAIDs Prodrugs based on Glutamic Acid Oligopeptides

2015

Zhao, Yi; He, Dongsheng; Ma, Lifang; Guo, Li

Letters in Drug Design & Discovery

..