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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RAKRRMEY | coumarin−triazole derivative 6 |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00234 |
| Smiles | |
| Inchi Key | InChIKey=BSRQIOHNQNKZPS-VUSFATCJSA-N |
| Molecular weight | 1445.75 |
| Molecular formula | C64H99N23O14S |
| Chemical name | Peptide information |
| Sequence (one letter) | RAKRRMEY |
| Length | 8 |
| Peptide name | Ubiquicidin (UBI) 31-38 |
| External ID | |
|---|---|
| CAS number | 1644441-61-1 |
| Other information | |
|---|---|
| Application | Antimicrobial, antifungal (Cryptococcus) |
| Additional function | Increased efficacy |
| Pharmacological class | antimicrobial, antifungal |
| Conjugate type | amide |
| Linker | no |
| Small molecule | coumarin−triazole derivative 6 |
| Small molecule CAS | 817638-71-4 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -7.67040 |
| Rotatable bonds | 47 |
| H bond donor | 18 |
| H bond acceptor | 26 |
| Polar surface area (PSA) | 612.89000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis | 2015 | Ferreira, Soraya Z.; Carneiro, Hellem C.; Lara, Hugo A.; Alves, Rosemeire B.; Resende, Jarbas M.; Oliveira, Heloisa M.; Silva, Luciana M.; Santos, Daniel A.; Freitas, Rossimiriam P. | ACS Medicinal Chemistry Letters | ||
