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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| XEYAARIEALIRAAQEQQEKNEAALRE | triazole | N-carboxyphenylpyrrole compound Gls-22 |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00208 |
| Smiles | |
| Inchi Key | InChIKey=JXECUYZOHDHQBR-RQTICMBSSA-N |
| Molecular weight | 3551.75 |
| Molecular formula | C157H238N46O49 |
| Chemical name | Peptide information |
| Sequence (one letter) | XEYAARIEALIRAAQEQQEKNEAALRE |
| Length | 27 |
| Peptide name | T2635-truncated peptide (HIV-1 fusion inhibitor) |
| External ID | |
|---|---|
| CAS number | 1975225-63-8 |
| Other information | |
|---|---|
| Application | Antimicrobial, antiviral (HIV-1) |
| Pharmacological class | antimicrobial, antiviral |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | triazole |
| Small molecule | N-carboxyphenylpyrrole compound Gls-22 |
| Small molecule CAS | 1975225-54-7 |
| Small molecule structure | |
| Structure method | 1H- anf 13C-NMR |
| NMR solvent | CDCl3 |
| Calculated properties | |
|---|---|
| LogP | -20.09831 |
| Rotatable bonds | 120 |
| H bond donor | 47 |
| H bond acceptor | 60 |
| Polar surface area (PSA) | 1563.64000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
An effective conjugation strategy for designing short peptide-based HIV-1 fusion inhibitors | 2016 | Liang, Guodong; Wang, Huixin; Chong, Huihui; Cheng, Siqi; Jiang, Xifeng; He, Yuxian; Wang, Chao; Liu, Keliang | Organic & Biomolecular Chemistry | ||
