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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| LMVGGVVIA | Trolox |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00188 |
| Smiles | |
| Inchi Key | InChIKey=MQJGRJLOLBFRRB-LRHZMXMYSA-N |
| Molecular weight | 1089.61 |
| Molecular formula | C53H87N9O13S |
| Chemical name | Peptide information |
| Sequence (one letter) | LMVGGVVIA |
| Length | 9 |
| Peptide name | amyloid-beta C-terminal motif |
| External ID | |
|---|---|
| CAS number | 1972631-86-9 |
| Other information | |
|---|---|
| Application | Alzheimer’s disease therapy, anti-aggregation and antioxidant |
| Pharmacological class | neurological |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Trolox |
| Small molecule CAS | 53188-07-01 |
| Calculated properties | |
|---|---|
| LogP | 3.59332 |
| Rotatable bonds | 29 |
| H bond donor | 11 |
| H bond acceptor | 13 |
| Polar surface area (PSA) | 328.66000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer’s disease | 2016 | Arai, Takuya; Ohno, Akiko; Kazunori, Mori; Kakizawa, Taeko; Kuwata, Hiroshi; Ozawa, Toshihiko; Shibanuma, Motoko; Hara, Shuntaro; Ishida, Seiichi; Kurihara, Masaaki; Miyata, Naoki; Nakagawa, Hidehiko; Fukuhara, Kiyoshi | Bioorganic & Medicinal Chemistry | ||
