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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RQIKIWFQNRRWA | Tobramycin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00168 |
| Smiles | |
| Inchi Key | InChIKey=RNTAVLKQTQMTLH-OPKXODCESA-N |
| Molecular weight | 2317.27 |
| Molecular formula | C104H164N36O25 |
| Chemical name | Peptide information |
| Sequence (one letter) | RQIKIWFQNRRWA |
| Length | 13 |
| Peptide name | antimicrobial peptides (AMP) |
| External ID | |
|---|---|
| CAS number | 2094990-96-0 |
| Other information | |
|---|---|
| Application | Antibiotic therapy, antibacterial |
| Additional function | Membrane active antibiotic peptide conjugates (MAAPCs), Outcome resistance and Improve antibacterial activity |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | triazole |
| Linker | no |
| Small molecule | Tobramycin |
| Small molecule CAS | 32986-56-4 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -14.32075 |
| Rotatable bonds | 68 |
| H bond donor | 35 |
| H bond acceptor | 43 |
| Polar surface area (PSA) | 1071.24000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes | 2017 | Deshayes, Stephanie; Xian, Wujing; Schmidt, Nathan W.; Kordbacheh, Shadi; Lieng, Juelline; Wang, Jennifer; Zarmer, Sandra; Germain, Samantha St.; Voyen, Laura; Thulin, Julia; Wong, Gerard C. L.; Kasko, Andrea M. | Bioconjugate Chemistry | ||
