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ConjuPepDB ID: cpd00140

Chemical structure


molecule
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cpd00140


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
NFGAILSS α-Cyano-4-hydroxycinnamic acid
Identification
ConjuPepDB ID

cpd00140

Smiles
Inchi Key

InChIKey=BDEHIECKZJXHSA-GZLFKYFISA-N

Molecular weight

978.445

Molecular formula

C46H62N10O14

Chemical name
Peptide information
Sequence (one letter)

NFGAILSS

Length

8

Peptide name

amyloid disrupting peptide

External ID
CAS number

2130904-45-7

Other information
Application

Type 2 diabetes therapy, amylin aggregation inhibition

Additional function

Self-assembly

Pharmacological class

neurological

Conjugate type

amide

Linker

no

Small molecule

α-Cyano-4-hydroxycinnamic acid

Small molecule CAS

28166-41-8

Small molecule structure

Calculated properties
LogP

-2.51661

Rotatable bonds

28

H bond donor

13

H bond acceptor

15

Polar surface area (PSA)

397.67000

Citations
ID Title Year Authors Journal DOI

Cpdart0036

Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation

2017

Profit, Adam A.; Vedad, Jayson; Desamero, Ruel Z. B.

Bioconjugate Chemistry

..