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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| FRARXRARXRAR | Nalidixic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00131 |
| Smiles | |
| Inchi Key | InChIKey=SYIPBLUAUZWXRB-NSCWMGFLSA-N |
| Molecular weight | 1834.12 |
| Molecular formula | C84H139N33O14 |
| Chemical name | Peptide information |
| Sequence (one letter) | FRARXRARXRAR |
| Length | 12 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 2133449-67-7 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy, antibacterial, DNA gyrase inhibition |
| Additional function | Improve activity and fluorescent labeling |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Nalidixic acid |
| Small molecule CAS | 0389-08-02 |
| Calculated properties | |
|---|---|
| LogP | -6.21252 |
| Rotatable bonds | 56 |
| H bond donor | 25 |
| H bond acceptor | 34 |
| Polar surface area (PSA) | 811.89000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Enhancing the Potency of Nalidixic Acid toward a Bacterial DNA Gyrase with Conjugated Peptides | 2017 | Ahmed, Marya; Kelley, Shana O. | ACS Chemical Biology | ||
