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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| LFMSCRTWKHYEQ | triazole | N-Methyl-N-phenylethenesulfonamide |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00066 |
| Smiles | |
| Inchi Key | InChIKey=ILEXXUYJFHVGOR-MEBISGPHSA-N |
| Molecular weight | 1924.84 |
| Molecular formula | C87H124N22O22S3 |
| Chemical name | Peptide information |
| Sequence (one letter) | LFMSCRTWKHYEQ |
| Length | 13 |
| Peptide name | model peptide |
| External ID | |
|---|---|
| CAS number | 2247055-84-9 |
| Other information | |
|---|---|
| Application | Synthesis, cysteine-Selective conjugation to prepare antibody-drog conjugates |
| Additional function | Posible applications as various imaging and therapeutic conjugates |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | triazole |
| Small molecule | N-Methyl-N-phenylethenesulfonamide |
| Small molecule CAS | 28792-97-4 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -8.78889 |
| Rotatable bonds | 60 |
| H bond donor | 24 |
| H bond acceptor | 28 |
| Polar surface area (PSA) | 725.87000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
N-Methyl-N-phenylvinylsulfonamides for Cysteine-Selective Conjugation | 2018 | Huang, Rong; Li, Zhihong; Sheng, Yao; Yu, Jianghui; Wu, Yue; Zhan, Yuexiong; Chen, Hongli; Jiang, Biao | Organic Letters | ||
