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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| LVRRFRRFFRRLRRCVLL | succinimide | Paclitaxel |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00035 |
| Smiles | |
| Inchi Key | InChIKey=WXHIBHYFXIKVDU-SUEZSGFHSA-N |
| Molecular weight | 3506.93 |
| Molecular formula | C169H255N45O35S |
| Chemical name | Peptide information |
| Sequence (one letter) | LVRRFRRFFRRLRRCVLL |
| Length | 18 |
| Peptide name | lytic peptides |
| External ID | |
|---|---|
| CAS number | 2305943-18-2 |
| Other information | |
|---|---|
| Application | Anticancer therapy, MCF-7 cells |
| Additional function | Targeting folate (FA) receptor and overcome drug resistance |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | succinimide |
| Small molecule | Paclitaxel |
| Small molecule CAS | 33069-62-4 |
| Small molecule structure | |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | -2.09763 |
| Rotatable bonds | 108 |
| H bond donor | 40 |
| H bond acceptor | 55 |
| Polar surface area (PSA) | 1338.75000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance | 2019 | Dai, Yuxuan; Cai, Xingguang; Bi, Xinzhou; Liu, Chunxia; Yue, Na; Zhu, Ying; Zhou, Jiaqi; Fu, Mian; Huang, Wenlong; Qian, Hai | European Journal of Medicinal Chemistry | ||
